Intelligibility, comprehensibility, and interpretability come to be problems in classroom interaction. Those 3 components contribute to flow of interaction, comprehend the message delivered, and to learning objectives attainment.This recent study was conducted by using qualitative research, in which the participants were from 2 universities with 4 different classes. then the research objectives should be constructed; to identify the intelligibility, comprehensibility, and interpretation problems in interaction between lectures and students; to investigate the extent of intelligibility,comprehensibility, and interpretation in facilitating lecturer-students communication; to depict students learning objective attainment by the practice of intelligibility, comprehensibility, and interpretation. This study using Qualitative research method. Purposes sampling was used in this study by choosing homogenous type. The data was collected through observation. Reading and analyzing references were able to sustenance the research data about the notion.This study clarified that the intelligibility, comprehensibility, and interpretability problems did not contribute significant problems to the participant due to the lecturer and the students are from same area, thus the cultural barriers were not be the core of barrier in the communication. It is more to the personal and interaction barriers of the students.