The existence of a co-19 pandemic that requires social distancing. Because the spread of this disease is very fast to move, and disrupt the human respiratory system. With the existence of this pandemic, the government is taking the policy in the field of education to carry out the process of learning from home. But it certainly does not reduce the ability of HOTS (high order thinking skills) of students to attend lectures during this pandemic. In the implementation process using learning based on blending learning. This is used to facilitate the integration of learning activities from face-to-face and online activities. The focus of this discussion emphasizes the description of blending learning itself. Then discuss the ability of HOTS (high order thinking skills), according to their cognitive level. As well as knowing the application of learning based on blending learning in improving the ability of HOTS (high order thinking skills) of PGMI STAIPANA students. The steps to improve HOTS (high order thinking skill) capabilities through blended learning are as follows: direct activities, independent learning, applications, tutorials, collaboration, evaluation and other supporting materials. In accordance with the level of cognitive abilities in high-level thinking (HOTS), namely: the ability to remember, the ability to understand, the ability to apply, the ability to evaluate and the ability to create. Certainly in accordance with the problems or topics provided by educators. In accordance with Qs. Fushsilat verse 25, Qs. Al Hasyr paragraph 2 and Ministerial Regulation No. 44 of 2015.