Piety is a vocabulary that is very popular among the Indonesian people, but not many of them understand it deeply. Whereas piety is a foundation must be held tightly by every human being. In the letter of Ath-Thalaq, there are several verses that discuss about piety. To know deeply about piety and wisdom contained therein, the research of the concept of piety in the letter of Al-Thalaq was raised, the study of Al-Misbah interpretation. After understanding the discussion, humans will be able to protect themselves from bad things. This research is a library research by using the maudhu’i (thematic) interpretation method. The primary data source is the book of Al-Misbah’s Interpretation by Muhammad Quraish Shihab. While the secondary data sources are the book of Al-Azhar’s Interpretation by Ham- ka, the book of Fii Zhilalil Qur’an Interpretation by Sayyid Quthb, books and journals that discuss the Science of the Qur’an which is related to the theme of this research discussion. This study uses documentation as a data collection technique and qualitative maudhu’i meth- od as data analysis. The analysis results of this study is known that piety in the letter of Ath-Thalaq according to Muhammad Quraish Shihab is an effort to carry out the commands of Allah Subhanahu wa Ta’ala as long as humans’ capabilities and stay away from His is prohibitions. Piety in the letter of Ath-Thalaq includes many things, including: Piety in matters related to thalaq and ‘iddah, piety after divorce, piety in matters of livelihood or rezeki after divorce, and piety in terms of the creation of heaven and earth. As for wisdom in terms of devotion contained in the letter Ath-Thalaq namely; getting a grant in the form of a rightful fortune that comes from an unexpected direction, getting help in the form of convenience in all matters, erased his mistakes and will get a double reward, getting a gift in the form of enjoyment of life in the world and put into heaven Allah ‘Azza wa Jalla.