To impredicate means to curse. If one is cursed by Allah Subhânahu wa Ta'ala, it means that he/she is kept away from His Grace and Blessings. Allah Subhânahu wa Ta'ala curses someone due to the misbehaviour she/he did, which are prohibited by Him. Once one is cursed by Allah Subhânahu wa Ta'ala, then Allah Subhânahu wa Ta'ala will not send any help. Therefore, we need to acknowledge the things which can cause the descent of Allah's impredications. This study aims to determine the interpretation of Allah's curses in the Holy Qur'an based on the interpretation contained in the Tafsir books of the Al-Qur'an Al-Adzim by Ibn Katsir and the Al-Mishbah by M. Quraish Shihab, as well as the similarities and differences between the two commentators. The data collection technique used is documentation technique. It is done by collecting data related to the object of research from the Tafsir books and other books relevant to the discussion. The research method used is comparative method, which is utilized by comparing the interpretation of the verses of the Holy Qur'an as represented in one book to another. The result of this research is that an impredication is interpreted as a curse. The similarity of interpretation between the two mufassirs lies in interpreting the nature of the cursing. According to both of them, when one is cursed by Allah Subhânahu wa Ta'ala, it means that he/she is removed from His Mercy and all the Blessings surrounded with it. The differences in the interpretation between the two commentators lies in the reason why Allah Subhânahu wa Ta'ala descended the impredication, specifically on the cursing of the Jews and the Children of Israel.