South Kalimantan has a diversity of cultures, regional peculiarities and even religions or beliefs. Diversity, especially in culture and religion, should be a priceless treasure and not cause social conflict. Religious harmony (Islam) related to social life in South Kalimantan is a benchmark or a model of harmony in a society with cultural diversity. Generation Z in South Kalimantan society has an important role in creating a model of Islamic harmonization in the midst of social conflicts that occur. The purpose of this study was to find out (1) Islamic values in Gen Z contained in cultural practices in South Kalimantan, (2) Supporting and inhibiting factors of the harmonization model of Islam in the social life of Gen Z in South Kalimantan. This study used descriptive qualitative method. The object of the research is the model of harmonization of Islam in social life, while the research subject is Gen Z in South Kalimantan. Collecting data in this study using observation and interview techniques. After the data was collected, it was analyzed descriptively and qualitatively. The results of this study are to describe the social life of gen Z in South Kalimantan in terms of Islamic values in the form of religious practices that build harmony in South Kalimantan, namely isra and mi'raj, yasinan, baayun maulid, and moon ashura, so that make a very good contribution to social life in society. Supporting factors in creating a model of Islamic harmonization, namely the model of accepting and perfecting (tahmil) and changing/reconstructing (tagyir) in the social life of gen Z through activities by building respect for the culture that exists in the people of South Kalimantan, and maintaining harmony can play a role in improving public awareness in understanding differences. The inhibiting factor of the Islamic harmonization model in building a harmonious society is that social conflict cannot be avoided, it can break the existing harmonization in the people of South Kalimantan.Keywords :Harmonization of Islam, Social Life, Generation Z