This paper discusses the fatwa of smoking contained in one of the Kerinci manuscripts written around the end of the 19th century AD. This kind of research is important to do because of the lack of research exploring religious manuscripts in the Kerinci area. This research was conducted using a qualitative research model that focuses on the domain of text and context. This study also uses a codicological approach to determine various aspects of the manuscript, such as material, age, place of writing, and estimates of script writing. In addition, a historical approach is also used to see the Kerinci context at that time. The data collection process was carried out by reviewing the available literature and also conducting an interview process to determine the background of the author, the age of the manuscript and the origin of the manuscript. The results of this study indicate that the manuscript containing the fatwa of smoking or smoking tobacco was written around the end of the 19th century AD. This is consistent with the indications of the calendar contained therein. The manuscript summarizes the prohibition of smoking based on the various arguments found in the Qur'an, Hadith, and the opinions of the scholars. Meanwhile, the motivation for prohibiting smoking contained in the manuscript is more likely to be influenced by religious factors, given the strong and rooted religious doctrine of the Kerinci community at that time compared to political, economic, and so on.