The aims of this study areto determine instructional communication in the teaching and learning process of teachers and children of ASD (Autism Spectrum Disorder) in the classroom. Based on a series of research activities conducted at the Prananda Bandung Educational Institution, instructional communication carried out by teachers in the teaching and learning process uses verbal messages in the form of language instruction and nonverbal messages. Between Language instruction and nonverbal messages both complement each other so that children of ASD (Autism Spectrum Disorder) can receive teaching material well. Giving verbal and nonverbal messages in the teaching and learning process conducted by the teacher in the classroom gives a change in the behavior of ASD (Autism Spectrum Disorder) children, behavior changes vary for each child, this is due to the unequal condition of children ASD (Autism Spectrum Disorder) , besides that parenting parents at home also play a role in changing children's behavior. The media used in the teaching and learning process is only visual media that helps children ASD (Autism Spectrum Disorder) to recognize material that is easily conveyed.