This study aimed to analyze the differences in parenting stress, perceptions of social support, self-compassion, and parenting practices between mothers of children with ASD and children with ADHD. Using the parental stress scale, the multidimensional scale of perceived social support, self-compassion scale, and parent construct, this study also aimed to analyze how the observed variables predicted the parenting practices among mothers of children with ASD and mothers of children with ADHD. An online survey was completed voluntarily by 34 mothers of children with ASD and 31 mothers of children with ADHD. MANOVA and regression analyses were conducted to support the hypothesis of the study. Results showed no significant difference in parenting stress, social supports, self-compassion, and parenting practices between the two groups. Parenting stress was revealed as a predictor for negative parenting practices among both groups. This research provides a picture of parenting practice among parents of children with ASD and ADHD in Indonesia, contributing to filling the gap concerning the limited available research in this field.