This study has successfully synthesized the hybrid particles combining poly(N-isopropylacrylamide) (PNIPAM) core and silica shell based on two approaches. With the first approach, N,N′-methylene bisacrylamide (MBA) is used as a cross-linking agent in the formation of particle core P(NIPAM/AM), followed by the deposition process of silica precursor on the core surface via sol-gel reaction in the presence of 3-glycidyloxypropyltrimethoxysilane (GLYMO). The result-ing hybrid particles P(NIPAM/AM/MBA)@silica have a spherical shape, perfect shell-core structure, narrow size distribution, and retains thermo-sensitive properties. However, the particle diameter is relatively large (ca. 563,5±28,2 nm). With the second approach (without MBA), the P(NIPAM/ AM)@silica hybrid particles are synthesized by using P(NIPAM/AM) chains in a shrinking state at 50°C as the nuclei for the silica encapsulation process in the presence of GLYMO. As a result, P(NIPAM/AM)@silica particles have shape, structure and properties similar to P(NIPAM/AM/ MBA)@silica particles but only 68.7±6.2 nm in diameter. The resultant particles with controlled particle morphology and physicochemical properties are useful for drug delivery system.