This study aimed to elaborate and examine the procedures for purification and prayer for health workers when using personal protective equipment (PPE). This research used a descriptive qualitative approach through content analysis techniques and library research. The results show that: First, it is an emergency condition that PPE is not applied, it will threaten the safety of his or her life in which he or she is vulnerable to infected with the virus; Secondly, before using PPE, health workers should have themselves purified from small hadas (impurity) through ablution or from the big one through bathing; Third, in the state of purity and nothing breaks the ablution, health workers can immediately pray as usual; Fourth, if their ablution is broken and they still must wear PPE while it is feared that time for prayer be over, then they should pray according to their circumstances even though they are obstructed from purification; Fifth, under certain situation, due to the job, health workers cannot perform prayers on time or cannot merge their prayers then they should immediately perform prayers whenever it is possible.