Abstract: Examination of blood creatinine levels is one of the parameters used to assess renal function, since serum and urinary excretion concentrations within 24 hours are relatively constant. However, in another clinical guideline, there is a type of examination that is more recommended in most patients with the risk of kidney failure, urine albumin test. In the event of renal dysfunction, the ability of creatinine filtration will decrease and serum creatinine will increase as well as some substances that should not exist in the urine, such as albumin, to appear. Reduced albumin excretion in the urine may be able to slow the rate of renal failure and help to delay the body’s need for kidney or dialysis transplantation. This cross-sectional study aims to analyze the relationship between serum creatinine and albuminuria in patients with kidney disease. Serum creatinine level examination by Jaffe method and urine albumin examination were qualitatively performed on the respondents who met the inclusion criteria. A total of 92 data were then analyzed by Chi-square with α<0,05. The results of this study indicate that there is a significant relationship between serum creatinine and albuminuria levels in patients with general kidney disease (p = 0.000, r = 0.728), and in male patients (p = 0.000, r = 0.736) and females (p = 0,000; r = 0.686) with the age level 41-50 years. There is no relationship between serum creatinine and albuminuria in male and female patients at the age of 20-30 years and 31–40 years.