Abstract: Cigarette smoke is the main cause of lung obstruction. One of the obstructions in real that is caused by cigarette smoke is oxidative stress. Oxidative stress trigger inflammation response occur and lung obstruction. Cigarette smoke able to cause lung histopathology changes like lungs obstruction on alveolus wall. Red dragon fruit extract tackle free radical then able to against the oxidative stress. The objective of this study to examines the image of rat lung histopathology under exposed cigarette smoke. Twenty four Wistar rats divided four groups: negative control, positive control, red dragon fruit extract treatment of 7,2 g/200 g WB, and red dragon fruit extract10,8 g/200 g WB. Negative control only given standard feed. Positive control given standar feed and exposed 21 cigarette per day. Treatment group given feed during 21 days. In the 22nd day rats be sacrificed, the lung taken out for observation and image of rat lung histopathology changes by making lung organ histopathology preparation hematoxicillin Eosion (HE) staining and observed under magnification light microscope 400x. The end result of the study indicate the finding of changes in lung histopathology such as obstruction level over the lung tissue higher, alveolar macrophage covered alveoli after being exposed cigarette smoke. Group which does not exposed cigarette smoke, lung alveolus macrophage in normal condition, there are no obstruction or alveolus macrophage occurred, its alveolar macrophage does no covering alveoli. Treatment group administered fruit dragon extract dose 10,8 g/200 g WB and dose 7,2 g/200 g WB seem almost the same with negative control treatment. Conclusion of the research is cigarette smoke expose can influence the number of alveolar macrophage on wistar rats. Suggestion very required further research on oxdative stress parameter.