Abstract: Adolescence signify of transition from childhood to adulthood is easy to having psychology and behavior problems, such as learning difficulty, anxiety, and drug addiction. School children as vulnerable group in drugs abuse behavior. The impact of drug abuse particularly alternately needle use get risk infection disease such as hepatitis B, C, and HIV. The objective of this research to examines the correlation between perception, sex, domicile status, parent status with drugs abuse behavior. This study used cross sectional analytical design with simple random sampling technique. Population of the research are students of 155 individuals, sample with 50 respondents. Data analysis employed chi square test. The result indicates that 83,7% having drugs abuse behavior with statistic test found there are no correlation between perception ( value = 0,826) and drugs abuse behavior, and found correlation between sex ( value = 0,001), domicile status relationship ( value = 0,001),parent status relationship ( value = 0,025), with drugs abuse behavior. Good communication among family members able to providing protection to child in order to avoid from drugs abuse. Good perception about drugs, stay with complete parents and in harmony has correlation to drugs abuse prevention.