This study aims to produce an Android-based “Smart Literacy Science” learning application and find out the app's feasibility in terms of material, media, and readability. The development of this application is based on the idea that mobile learning (m-learning) in learning is a trend and has a positive impact on digital literacy capabilities in the 21st century. The use of mobile learning (m-learning) quickly, precisely, and practice can improve students' Science abilities. The type of research used is the type of research and development (research and development). The application made with the APK./android extension which is the android operating system is the smartphone operating system most widely used in Indonesia. The research method used were combination of two development models namely ADDIE (Analyze, Design, Develop, Implementation and Evaluation) and 4-D (Define, Design, Develop, and Disseminate) that produce the ADDIED development model (Analyze, Design, Develop, Implementation, Evaluation & Disseminate). Based on the research result, conluded that the learning application "Smart Literacy Science" that already uses the Android operating base. This application contains subject matter (videos, practical designs, and virtual labs) and a self-evaluation system. This application has been tested for eligibility in terms of material, media, and legibility, where the results of data analysis using the AikenV Formula are above 0.7. Thus it can be concluded that the Android-based Smart Literacy Application is feasible to use and is effective in improving students' scientific abilities.