Premenstrual Syndrome (PMS) is a common health problem most commonly reported by women of reproductive age. Factors main cause is due to an imbalance in the work of the hormones estrogen and progesterone as well as a change in serotonin levels. Approximately 30-80% of women experience mood disorders (mood) or somatic (or both) that occur during the menstrual cycle. Based on the report by the World Health Organization (WHO) reported that the symptoms of pre-menstrual syndrome experienced by 65.7 in adolescent girls. One of the factors associated with pre menstual syndrome is a physical activity. The purpose of this study was to determine the incidence of physical activity with pre menstrual syndrome. Methods: This type of research is quantitative with cross sectional design. Subjects were SMP PGRI performances were about 40 people. The sampling technique using total sampling. analysis using Chi Square test. The result showed the p value of 0.035, which means there is a relationship of physical activity with pre menstrual syndrome.Key Word : Physical activity, Premenstrual syndrome