Diarrhea is one of the major health problems for people in Indonesia which is one of the biggest causes of death among children under five and children. In Indonesia, approximately 162 thousand children under five and children die each year or about 460 toddlers and children per day. Outbreaks of diarrhea often struck Indonesians, as Indonesia is an endemic region of diarrhea caused by climate change and poor environmental health. The purpose of this study was to determine the relationship between the home environment with the incidence of diarrhea in infants. The research design using cross sectional research design with the number of samples of 60 houses whose mothers can be used as respondents. The result of the research on 60 mothers obtained the result that unhealthy environment condition there are 32 houses (53,3%), healthy environment is 28 house (46,7%). For the incidence of diarrhea as many as 20 people (33.3%) and who did not experience diarrhea as many as 40 people (66.7%). Chi Square statistical test to see the environmental relationship with diarrhea occurrence proved statistically significant with p value = 0.001. For health workers need to increase early awareness of the incidence of diarrhea, water quality improvement and improvement of environmental sanitation programs so important things, for the community should always make improvements in environmental sanitation on family members to prevent the incidence of diseases, especially diarrhea can be resolved. Families are expected to actively seek information from nearby health services and various media and the need for high awareness in preventing diarrheal diseases.