Implementation of Tri Hita Karana main goal is to realize a harmonious relationship between man and God, human with human and human with nature environment. Tri Hita Karana has been applied well by Hindu Transmigration society living in Nusa Agung Village of OKU Timur Regency of South Sumatera Province. To realize this harmonious relationship there must be a process or forms of activities implemented to realize harmony. So in this study there are three formulation of the problem to know the process or forms of activities that build harmony. (1) How to apply Tri Hita Karana to build harmony of Hindu transmigration society from Bali in Nusa Agung Village of East OKU Regency of South Sumatera Province, (2) How to apply Tri Hita Karana to build harmony of Balinese Hindu transmigration community in Nusa Agung Regency OKU East of South Sumatera Province and (3) What is the philosophical meaning contained in the implementation of Tri Hita Karana in establishing the harmony of Hindu transmigration society from Bali in Nusa Agung Village OKU Timur Regency of South Sumatera Province.The theory used in this study to discuss the formulation of the problem is (1) Symbolic Interactionism Theory to dissect the problem about how Tri Hita Karana application form. (2) Structural Functional Theory to dissect the problem about how the function of Tri Hita Karana implementation. (3) Theory of Meaning to dissect the problem of what philosophical meaning is contained in the application of Tri Hita Karana. The method used in this research is the method of informants, data collection methods, data analysis methods and methods of presentation. The method of determining informants using Porposive sampling technique, data collection method using method; Obsevation, interviews, literature and documentation. Methods of data analysis using qualitative descriptive method and the type of research is qualitative.The results obtained in this study are (1) the form of Tri Hita Karana implementation in establishing the harmony of the Hindu transmigration community from Bali in Nusa Agung Village divided into several forms, namely; Form of ritual, form, form of marriage, form of work, form of gotong royong and form of agriculture. (2) the function of Tri Hita Karana implementation in establishing the harmony of Hindu transmigration community from Bali in Nusa Agung village divided into three functions, namely; Religious functions, social functions and economic functions. (3) philosophical meaning contained in the application of Tri Hita Karana in establishing harmony of Hindu transmigration society from Bali in Nusa Agung village divided into three meanings, namely; The nature of human relationships with God, the nature of human relationships with humans and the nature of human relationships with the natural environment.