The aims of this research are to describe students’ responses and to know the substantive theories that can be formulated from the reality of students’ responses to the use of Information Technology (IT) in the English teaching-learning at SMK Ma’arif 5 Gombong. Type of research is a qualitative naturalistic with subjects X and XI grade students. The subjects of the research are students from multimedia, office administration, accounting and automotive study program of SMK Ma’arif 5 Gombong in academic year 2017/2018 which consists of 30 students.The data were obtained from students directly in the class by using an open questionnaire. Data analysis techniques inthis researchcarried outby categorical analysis and descriptive analysis.The results showed that there were 141 students’responses which were divided into two major group consisted of 77 students’ positive responses and 64 students’ negative responses. These all responses were broken down into 22 categories. Based on the descriptive data analysis, there were 5 prominent of students’ responses toward the use of IT in the English teaching learning. They were 3 positive responses in relation to process, method and material. Then, there were 2 negative responses in relation to physics and attitude. There were also obtained 5 substantive theories to the use of IT in the English teaching learning. They were 3 positive substantive theories which explained that IT gave the effectiveness and efficiency, IT could make easier in getting English material and IT could improve student’s learning outcomes. Then, there were 2 negative substantive theories which explained that IT was able to cause a noisy learning process and IT made an uncomfortable learning process if IT was not prepared properly. On the basis of the results of this research showed that there were many advantages of the use of IT more than its disadvantages. Therefore, it can be suggested for English teachers to use IT in their teaching-learning process.