The purpose of this study was to to explore mothers experience in caring for preterm infants who had been treated in the NICU in Bengkulu. This study used a qualitative design with in depth interviews using open ended questions as a guide. The study was conducted in a patients home in a fairly comfortable space. The sample consisted of five mothers. Data were analyzed using Collaizi method. The results obtained are six themes, namely the mothers description of the characteristics of preterm infants, the cause of preterm birth, the mothers experience in preterm baby care at home, the support the mother receives in preterm infant care, mothers self-coping in the care of preterm infants and reactions mother during caring for preterm baby. The conclusion that can be taken is that mothers experience in caring for preterm baby who had been treated in NICU room of Bengkulu City should be able to pay attention to some obstacles or challenges that need to be considered during home treatment. In general, the mother is able to pass a period of sadness and grief in treating preterm infants or low birth weight. Keywords:Phenomenology, Mothers Experience,Preterm.