This study aimed to describe the factors that affect the quality of life of patients with CRF who undergo hemodialysis in dr. M. Yunushospital in Bengkulu 2016. The population of study is 205 people, the sampling technique used was an accidental sampling with a sample of 67 respondents.The results showed nearly all respondents aged smaller than 20 and greather than 35 years, more than the majority of respondents were female, more than the majority of respondents had pretty income or more, almost half of respondents had high levels of depression, more than the majority of respondents had either the family support, more than the majority of respondents had a high quality of life, there was a correlation between age, gender, producer, depression, and family support with quality of life, there was a relationship between sex with the quality of life for CRF patients undergoing hemodialysis in dr. M. Yunus Hospital in Bengkulu 2016.It is advisable for the public to provide health education for families of patients with CRF who undergo hemodialysis therapy on the importance of family support in improving the quality of life of family members. Keywords: Accidental Sampling, Chronic Kidney Disease, Hemodialysis, Quality of Life.