The purpose of this study was to determine the factors associated with the incidence of schizophrenia in patients in the Inpatient Room of Soeprapto Special Base Hospital of Bengkulu Province.The method used is descriptive research design with cross sectional approach. Data were collected using primary and secondary data, primary data obtained from the questionnaires to the 67 families of patients treated in inpatient Special Hospital Mental Soeprapto Bengkulu province, while secondary data is taken from the patient's medical record. The sampling technique is by proportional random sampling technique. The analysis showed the majority of respondents, 39  who suffered from schizophrenia, the majority of respondents, 15 contained genetic factors, the majority of respondents, 24 Which there are psychosocial factors, and some of the respondents are 24 people that there are environmental factors. The results of the bivariate analysis showed no significant relationship between genetic schizophrenia in patients in the inpatient unit Special Hospital Mental Soeprapto Bengkulu province, there is a significant relationship between psychosocial with schizophrenia in patients in the inpatient unit Special Hospital Mental Soeprapto Bengkulu province, and there are A significant relationship between the environment and schizophrenia in patients in the inpatient rooms of Soeprapto Special Base Hospital of Bengkulu Province. Keywords: Genetic, Psychosocial, Environmental, Schizophrenia