The Causes of Misinterpretation in the Qur’an. Islam becomes the largest religion in the world today which makes most of everybody knows what is Islam and what is Qur’an. A deep understanding about truly Islam and Qur’an is needed, because everybody in this particular time can interpret Moslem’s holy book, Qur’an. A lack of understanding the Qur’an and reading or learning it from unqualified sources can take Moslems losing their true knowledge and faith. Liberty of speech and argumentation appears with some interpreters to write and speak about the content of Qur’an and disseminate it to society, including orientalists who have been becoming very famous in Islamic world with their explanations about Qur’an and Hadits. Some orientalists certainly have a good understanding about it which make their works are able being references for Moslems and everyone who is interested in studying Qur’an. Others, interpret the Qur’an and Hadits to destroy the true content of it. Interpreters who do not have a pure purpose interpreting Qur’an are not only from orientalists, but also from its own religion, Moslems. Their orientation interpreting Qur’an is not for people’s reconciliation, but it is more for their own importance and political interest of themselves, especially who follow their passions. Several Moslem interpreters have no high quality in Arabic to interpret it and do not follow interpretation rules which have been compromised. Those aspects can absolutely cause misinterpretation in the Qur’an. Keywords: Islam, Moslems, Qur’an, interpretation, interpreters