Nowadays, the discourses of religion pluralism is one of the frequently-discussed issue among muslim. This case appears along with the emergence of books, works, writings in the mass media, congress, seminars, discussions, and dialogue which are focusing on the religion pluralism. One of the factors causing the emergence of this discourse is a number of conflicts that happened among different religious adherents which was often began by an excessive truth claim. The discourse presented in this paper aims to create harmony life and peace among different religion adherents. Al-Qur’an both admits the existence of other religions and commands its followers to live in harmony as well as respect each other. Islam is “rahmah lil ’ālamīn”, but yet the reality that happens in muslim world is not in line with the ideality. So the question arises in our minds; where is Islam as rahmah lil ’ālamīn? the fact is there are still many muslim who can’t wisely face the plurality as it has been taught by the Qur’an. So how is the Qur’anic guidance to face the plurality? Based on this reason, this article would like to discuss on the Qur’anic guidance in facing the religion pluralism using descriptive-analysis method.