Lamaholot language has some functions that very prominent for speaker in society. The functions are social function, economic function and cultural function. This study is about the affixation of Lamaholot language used in Lohayong village of East Solor sub-district, East Flores regency.  This study tries to answer two problems, namely what affixes found in Lamaholot lexicon are and what the processes and meanings of the affixes of Lamaholot language used in Lohayong village of East Solor sub district are. Therefore, it has objectives to describe the processes and the meanings of affixation of Lamaholot language in East Solor sub district. It employs descriptive qualitative method. The data of this writing is taken from Lamaholot books and informants’ interview. Research shows that there are six prefix and infix. Suffix of Lamaholot language mostly used in East Solor sub-district is not found. Phonologically, there is an extensive presence of nasal sounds /m/ /n/ and /N/ as a result of phonological changes among affixes and their roots.