Detection of EGFR mutation and its association with clinicopathological features of non-small cell lung cancer patients
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Tran Huu ThienThe University of Danang - VN-UK Institute for Research and Executive EducationNguyen An Thi VietThe University of Danang - VN-UK Institute for Research and Executive EducationDoan Minh ThuThe University of Danang - VN-UK Institute for Research and Executive EducationNguyen Ngoc QuangPathology and Molecular Biology Center, National Cancer Hospital K, HanoiVuong Dieu LinhPathology and Molecular Biology Center, National Cancer Hospital K, Hanoi
Từ khóa:
Ung thư phổi không tế bào nhỏ
Đặc điểm bệnh lý lâm sàng
Đột biến EGFR
Tóm tắt
Alterations in the epidermal growth factor receptor were confirmed to take a significant role in targeted therapy for patients with lung cancer. Studied 299 non-small cell lung cancer patients to determine the distribution of EGFR mutation and its relationship with clinicopathological characteristics of patients. EGFR mutations were analysed by allele-specific PCR on the Cobas z480 system, and the association between EGFR mutations and patient characteristics was analysed by Pearson Chi-square test and Fisher extract test. The results showed that the frequency of EGFR mutation was 38.8%, in which, Ex19Del and L858R substitution were predominant among overall mutation, 45.4% and 29.1%, respectively. There was no difference between EGFR mutations with age, specimen type, tumour size and histopathological subtype. However, there was a strong correlation between EGFR mutation and gender and tumour status (p<0.05). In particularly, Ex19Del and L858R mutation were positively associated with females, while the G719X substitution mainly occurred in male patients.
Tài liệu tham khảo
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Dec 31, 2022
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Tran Huu Thien, Nguyen An Thi Viet, Doan Minh Thu, Nguyen Ngoc Quang, và Vuong Dieu Linh. “Detection of EGFR Mutation and Its Association With Clinicopathological Features of Non-Small Cell Lung Cancer Patients”. Tạp Chí Khoa học Và Công nghệ - Đại học Đà Nẵng, vol 20, số p.h 12.1, Tháng Chạp 2022, tr 47-51, doi:10.31130/ud-jst.2022.292E.
